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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
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MRI-based method for lower urinary tract dysfunction in adult male mice
Dalton T McLean1,2, David R Rutkowski3,4, Teresa Liu1,5
1Urology, University of Wisconsin Madison, WI, USA.
American Journal of Clinical and Experimental Urology
|July 19, 2019
Summary
Magnetic resonance imaging (MRI) offers a faster, more accurate method for studying mouse models of lower urinary tract dysfunction (LUTD). This technique allows detailed visualization and quantification of urogenital tract anatomy, aiding BPH/LUTS research.
Area of Science:
- Veterinary Medicine
- Medical Imaging
- Urology
Background:
- Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) significantly impact aging men's quality of life.
- Current mouse models for studying BPH/LUTS involve lengthy, multi-technique analyses for endpoint evaluation.
- Advancements in magnetic resonance imaging (MRI) present an opportunity for more efficient and precise analysis.
Purpose of the Study:
- To demonstrate the utility of MRI for analyzing lower urinary tract dysfunction (LUTD) in mouse models.
- To showcase MRI's capability for both qualitative and quantitative assessment of urogenital tract structures.
Main Methods:
- Whole and partial mouse urogenital tracts were imaged using a 9.4 Tesla MRI system.
- A specialized device was developed to facilitate high-throughput imaging of up to 100 specimens per session.
- Image processing focused on qualitative resolution assessment and quantitative measurement of anatomical components.
Main Results:
- MRI successfully resolved and quantified fine anatomical structures, including ureters, urethra, ductus deferens, seminal vesicles, bladder, and prostatic lobes.
- High-resolution imaging provided detailed qualitative representations of urogenital tract tissues.
- Quantitative measurements of various urogenital tract components were achieved.
Conclusions:
- MRI is a powerful, time-efficient tool for analyzing mouse models of LUTD.
- The technique enables detailed visualization and precise quantification of urogenital structures.
- This approach holds potential for improved lesion detection, diagnosis, and tracking of LUTS progression in research settings.
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