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Updated: Jan 22, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
Published on: March 17, 2014
Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of Lactococcus lactis
Tetsu Sugimura1, Kenta Jounai1,2, Konomi Ohshio1
1Central Laboratories for Key Technologies, Kirin Co. Ltd ., Yokohama , Japan.
Abstract:
Plasmacytoid dendritic cells (pDCs) are crucial in anti-viral immunity, acting as regulators in both adaptive and innate immunity. In this study, brief heat stress caused a decrease in splenic pDC activity in mice. Administration of Lactococcus lactis strain Plasma (LC-Plasma) significantly suppressed the decrease in pDC activity and IFN-α production. Abbreviations: LC-Plasma: Lactococcus lactis strain Plasma; LAB: lactic acid bacteria; pDC: plasmacytoid dendritic cell; IFN: interferons; mDC: myeloid dendritic cells.
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