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Immuno-oncology for surgeons.
S L Lee1,2,3, A Al-Shamkhani2, A Mirnezami1,3
1Southampton Cancer Research UK Centre, University of Southampton, Southampton, UK.
The British Journal of Surgery
|July 19, 2019
Summary
Immuno-oncology therapies are revolutionizing cancer care, offering new ways to mobilize the immune system against cancer. This review updates surgeons on these agents, their toxicities, and their integration with cancer surgery.
Area of Science:
- Oncology
- Immunology
- Genomics
- Molecular Biology
Background:
- Traditional cancer treatments focus on targeting neoplastic cells directly.
- Advances in genomics and molecular techniques enable personalized cancer therapies.
- Immunology breakthroughs provide a mechanistic understanding of immune system mobilization against cancer.
Purpose of the Study:
- To provide an update on immuno-oncology agents for surgical oncologists.
- To discuss the mechanisms of action of current immuno-oncology therapies.
- To summarize emerging toxicities and data on combining surgery with immuno-oncology.
Main Methods:
- Review of current immuno-oncology agents and their mechanisms.
- Discussion of surgically relevant toxicities associated with immuno-oncology.
- Summary of clinical data on sequencing and combining cancer surgery with immuno-oncology treatments.
Main Results:
- Immuno-oncology agents are rapidly transforming cancer care.
- Clinical trials of immune-modifying agents have increased exponentially.
- Surgical oncologists will increasingly manage patients treated with neoadjuvant or adjuvant immuno-oncology.
Conclusions:
- Immuno-oncology represents a significant advancement in cancer treatment.
- Understanding immuno-oncology mechanisms and toxicities is crucial for surgeons.
- Integration of immuno-oncology with surgical interventions is a key area for future cancer care.
