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Updated: Jan 22, 2026

In Vitro Culture of Epithelial Cells from Different Anatomical Regions of the Human Amniotic Membrane
Published on: November 28, 2019
A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment
Tomaso Caporossi1, Lorenzo De Angelis1, Bianca Pacini1
1Department of Translational Surgery and Medicine, Ophthalmology, University of Florence, Careggi, Florence, Italy.
Objective:
To assess the efficacy of the human amniotic membrane (hAM) to treat (HMMH) associated with retinal detachment (RD).
Material And Methods:
Ten eyes of 10 patients with recurrent HMMH and RD, who had already undergone one or more pars plana vitrectomy (PPV), underwent a PPV with an hAM plug implanted in the macular hole. The initial five patients enrolled were tamponaded with (SO) while the subsequent five patients with 10% octafluoropropane (C3 F8 ). Silicon oil was removed in all five patients 2 months later. No statistical differences were reported between the two groups.
Results:
Final retinal reattachment was achieved in all the patients. BCVA improved from 1.73 logMAR to 0.94 logMAR after 6 months. No adverse events were registered during follow-up.
Conclusion:
An hAM plug is an efficient substrate to manage HMMH associated with RD resulting in encouraging visual acuity recovery.
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