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Updated: Jul 27, 2026

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
Published on: October 26, 2009
Gum ghatti based hydrogel: Microwave synthesis, characterization, 5-Fluorouracil encapsulation and 'in vitro' drug
Pinki Pal1, Srikant Kumar Singh1, Sumit Mishra1
1Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India.
Abstract:
The release attributes of anticancer therapeutic embedded in programmable gum ghatti hydrogel matrices has been evaluated. Hydrogel has been programmed simply by adjusting the product composition (monomer-acrylamide and crosslinker- N, N Methylenebisacrylamide (MBAm)) to control mesh size during copolymerization of gum through microwave based technique. The synthesized system has been characterized for physicochemical traits and 'in-vitro' drug release in various physiological pH conditions by USP standard method. The degree of crosslinking analysed through equilibrium swelling ratio (ESR) has been correlated with release kinetics. The release profiles yielded from the measurements of cumulative drug delivery showed that the system with lower ESR included slower release rate than that of the system with higher ESR, consequently generated higher t50 values. Additionally, the release rate rises with rise in pH milieu.
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