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Complete Genome Sequence of Staphylococcus aureus Siphophage Sebago
Kathryn Klotz1, Abby Korn1, Heather Newkirk1
1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.
Microbiology Resource Announcements
|July 20, 2019
Summary
We sequenced the Sebago siphophage genome, a virus infecting Staphylococcus aureus. This phage is closely related to the Phietavirus family.
Area of Science:
- Microbiology
- Virology
- Genomics
Background:
- Staphylococcus aureus is a significant human pathogen.
- Bacteriophages, or phages, are viruses that infect bacteria and are potential therapeutic agents.
Purpose of the Study:
- To introduce and characterize the genome of Sebago, a novel siphophage.
- To determine the phylogenetic relationship of Sebago to other known phages.
Main Methods:
- Genome sequencing of the Sebago siphophage.
- Bioinformatic analysis of the phage genome.
- Comparative genomics with related phage genomes.
Main Results:
- The Sebago genome is 43,878 base pairs long.
- The genome encodes 70 proteins.
- Sebago is phylogenetically most similar to StauST398, a member of the Phietavirus genus.
Conclusions:
- The characterization of the Sebago siphophage genome provides new insights into phage diversity.
- Understanding Sebago's genomic features aids in exploring its potential applications, such as in phage therapy against Staphylococcus aureus.
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