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Updated: Jan 22, 2026
09:22
Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
Published on: November 4, 2015
12.6K
Omalizumab as a Provoking Factor for Venous Thromboembolism
Crhistian-Mario Oblitas1, Francisco Galeano-Valle1,2, Laura Vela-De La Cruz1
1Venous Thromboembolism Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Drug Target Insights
|July 20, 2019
Summary
Omalizumab, an asthma medication, may increase the risk of serious blood clots like pulmonary embolism and deep vein thrombosis. Further research is needed to confirm this potential adverse drug reaction.
Area of Science:
- Immunology
- Pharmacology
- Pulmonology
Background:
- Omalizumab is a monoclonal antibody targeting IgE, used for severe asthma and chronic urticaria.
- Thromboembolic events are a potential concern with biologic therapies.
Purpose of the Study:
- To report a case of probable omalizumab-associated venous thromboembolism.
- To review existing evidence on omalizumab and thromboembolic risk.
Main Methods:
- Case report of a patient developing deep vein thrombosis and pulmonary embolism.
- Review of postmarketing data and literature regarding omalizumab safety.
Main Results:
- A 43-year-old patient on omalizumab developed bilateral pulmonary embolism, pulmonary infarction, and deep vein thrombosis.
- The Naranjo scale indicated a probable adverse drug reaction to omalizumab.
- The EXCELS study suggested an increased risk of venous thromboembolism with omalizumab.
Conclusions:
- Omalizumab may be associated with an increased risk of arterial and venous thromboembolic events.
- While evidence is not definitive, this association warrants further investigation and clinical vigilance.
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