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The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
Published on: June 30, 2014
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The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in
Daniel Merlo1, David Darby2, Tomas Kalincik3
1Department of Neuroscience, Central Clinical School, Monash University, Level 6, 99 Commercial Road, Melbourne, Victoria 3004, Australia.
Therapeutic Advances in Neurological Disorders
|July 20, 2019
Summary
MSReactor offers a scalable, reliable tool for monitoring cognitive function in multiple sclerosis (MS) remotely. This web-based battery effectively tracks subtle cognitive changes, aiding in disease progression assessment.
Area of Science:
- Neuroscience
- Clinical Psychology
Background:
- Current multiple sclerosis (MS) cognitive tests are resource-intensive and limited by practice effects, hindering frequent retesting.
- There is a critical need for brief, reliable monitoring tools to detect subtle, subclinical cognitive changes in MS patients.
- Longitudinal cognitive monitoring could redefine disease progression, complementing existing clinical assessments.
Purpose of the Study:
- To evaluate MSReactor, a web-based cognitive testing battery, for its reliability, validity, and feasibility in monitoring cognitive function in people with MS.
- To assess the correlation of MSReactor with established cognitive tests and its sensitivity to MS-related cognitive changes.
- To determine the acceptability and practice effects associated with MSReactor, particularly for remote home-based testing.
Main Methods:
- MSReactor, a web-based battery, was used to measure psychomotor speed, visual attention, and working memory via simple reaction time tasks.
- Participants completed clinic-based assessments at baseline and semi-annually, with remote home testing conducted quarterly.
- Acceptability, quality of life, depression, and anxiety were assessed alongside correlations with the Symbol Digit Modalities Test (SDMT), practice effects, and test-retest reliability.
Main Results:
- A cohort of 450 MS patients was recruited, with 81% engaging in home-based testing, demonstrating high adherence.
- The MSReactor tasks showed high participant acceptability (96% willing to repeat) and minimal anxiety reported.
- Practice effects stabilized within three tests, and MSReactor performance correlated with SDMT scores, with MS patients performing slower than controls.
Conclusions:
- MSReactor is a scalable and reliable cognitive screening tool suitable for both clinic and remote use in multiple sclerosis management.
- The tool demonstrated correlation with a validated cognitive test and sensitivity to MS, identifying baseline predictors of cognitive performance.
- MSReactor facilitates frequent, accessible cognitive monitoring, supporting early detection of changes and potentially refining disease progression assessment.
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