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Updated: Jan 22, 2026
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
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Synchronous Breast Implant-associated Anaplastic Large Cell Lymphoma and Invasive Carcinoma: Genomic Profiling and
Rita A Mukhtar1, Michael Holland1, David A Sieber2
1Department of Surgery, University of California San Francisco, San Francisco, Calif.
Plastic and Reconstructive Surgery. Global Open
|July 20, 2019
Summary
This case highlights a rare instance of synchronous breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) and invasive ductal carcinoma. Genetic analysis revealed distinct mutations in each tumor, emphasizing comprehensive evaluation for concurrent malignancies.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare malignancy.',
- Co-occurrence of BIA-ALCL with other breast cancers is infrequently reported.
Purpose of the Study:
- To report a unique case of synchronous BIA-ALCL and invasive ductal carcinoma in the same breast.',
- To analyze the distinct genetic profiles of these concomitant malignancies.
- To underscore the importance of thorough oncologic evaluation in patients diagnosed with BIA-ALCL.
Main Methods:
- Next-generation sequencing was performed on both the BIA-ALCL and invasive ductal carcinoma samples.',
- Clinical data regarding patient history, diagnosis, and treatment were reviewed.
- Management strategies and follow-up were documented.
Main Results:
- The BIA-ALCL exhibited an activating STAT3 mutation.',
- The invasive ductal carcinoma showed a PIK3CA in-frame deletion, with mutations being mutually exclusive between the two tumors.
- The patient underwent surgical removal of implants and tumors, followed by adjuvant therapies, with no recurrence at 1 year.
Conclusions:
- This case demonstrates the occurrence of distinct genetic aberrations in synchronous BIA-ALCL and invasive ductal carcinoma.',
- Comprehensive diagnostic workup is crucial for identifying concomitant malignancies in patients with BIA-ALCL.
- Current management guidelines for BIA-ALCL should emphasize thorough evaluation for other breast cancers.
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