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Updated: Jan 22, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
One-Pot Asymmetric Synthesis of Spiropyrazolone-Linked Cyclopropanes and Benzofurans through a General Michael
Hong Lu1,2, Huan-Xin Zhang1, Chang-Yin Tan1
1State Key Laboratory of Applied Organic Chemistry, School of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
Abstract:
A sequential and general strategy has been successfully developed for the synthesis of spiropyrazolone scaffolds. This intriguing transformation of the asymmetric multicomponent catalysis process was realized with the combination of Michael addition/chlorination/nucleophilic substitution in a one-pot sequence, giving rise to a series of spiropyrazolones with fully substituted cyclopropanes and spiro-dihydrobenzofurans containing continuous stereogenic centers in good yields with excellent stereoselectivities.
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