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Comparing objective and self-reported measures of adherence in haemophilia

Vanessa Giroto Guedes1,2, José Eduardo Corrente2, Albert Farrugia3

  • 1Blood Center of Marília Medical School, FAMEMA, Marília, Brazil.

Haemophilia : the Official Journal of the World Federation of Hemophilia
|July 20, 2019
PubMed

Insights

Subjective adherence measures in haemophilia differ significantly from objective assessments, potentially overestimating patient compliance. This highlights the need for objective evaluations in haemophilia prophylaxis studies.

Area of Science:

  • Hematology
  • Clinical Research
  • Patient Adherence Studies

Background:

  • Adherence to prophylaxis is crucial for managing haemophilia.
  • Subjective self-reports are commonly used to assess adherence but may be biased.

Purpose of the Study:

  • To compare subjective and objective measures of adherence to clotting factor concentrate (CFC) prophylaxis in haemophilia patients.

Main Methods:

  • A cross-sectional study comparing self-perceived adherence and CFC vial return data.
  • Objective adherence was determined by counting returned CFC vials.

Main Results:

  • No significant correlation between self-perceived adherence and objective classification.
  • Moderate correlation found between self-reported and objectively measured missed CFC doses.
  • Self-perceived adherence was rated higher than objective assessments.

Conclusions:

  • Significant discrepancies exist between subjective and objective adherence measures in haemophilia.
  • Social desirability bias and differing concepts of adherence may explain discrepancies.
  • Studies relying solely on self-reports may overestimate adherence to haemophilia prophylaxis.
Abstract

Keywords:
Brazildeveloping countrieshaemophiliamedication adherencepatient compliance

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