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METABOLIC, ENZYMATIC AND MINERAL MAINTENANCE OFREPARATIVE OSTEOGENESIS OF FACIAL CRANIUM INJURIES
1Kharkiv National Medical University of the Ministry of Health of Ukraine.
Georgian Medical News
|July 20, 2019
Summary
Complicated facial bone injuries disrupt reparative osteogenesis, indicated by altered enzyme and metabolite levels. These biochemical changes correlate with impaired bone healing and density.
Area of Science:
- Biochemistry
- Orthopedics
- Traumatology
Background:
- Facial cranium injuries can have complicated courses, impacting bone healing.
- Assessing reparative osteogenesis requires evaluating biochemical markers and bone metabolism.
Purpose of the Study:
- To investigate marker enzymes, hormonal, and carbohydrate-protein indicators of reparative osteogenesis in complicated versus uncomplicated facial cranium injuries.
- To correlate biochemical findings with bone tissue structural and functional states.
Main Methods:
- Studied 81 patients with facial cranium injuries, divided into complicated and uncomplicated groups.
- Analyzed urinary hydroxyproline excretion, alkaline and acid phosphatase activity, serum calcium, phosphorus, and glycosaminoglycans.
- Utilized densitometry to assess bone tissue structure and function.
Main Results:
- Complicated injuries showed increased phosphorus, uronic acids, and oxyproline excretion, with decreased magnesium excretion.
- Serum calcium levels were significantly lower in complicated cases, suggesting reduced metabolic activity in osteogenesis.
- Elevated chondroitin-6-sulfates and altered glycosaminoglycan fractions indicated osteogenesis instability.
- Densitometry revealed increased ultrasonic attenuation and decreased speed, linked to low chondroitin-6-sulfates.
Conclusions:
- Biochemical markers and densitometry can identify impaired reparative osteogenesis in complicated facial cranium injuries.
- Altered mineral and carbohydrate-protein metabolism are key indicators of disrupted bone healing.
- Damage to central mechanisms may underlie the reduced metabolic activity observed in complicated cases.
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