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Updated: Jan 22, 2026
09:12
Characterization of Human Monocyte Subsets by Whole Blood Flow Cytometry Analysis
Published on: October 17, 2018
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Prognostic impact of circulating monocyte subsets in pediatric solid tumors
Asmaa M Zahran1, Amal Rayan2, Heba Abdel Razik Sayed3
1Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.
Cancer Biomarkers : Section a of Disease Markers
|July 20, 2019
Summary
In pediatric solid tumors, intermediate and non-classical monocytes were linked to better treatment responses. Non-classical monocytes also showed a positive correlation with overall survival in these young patients.
Area of Science:
- Immunology
- Pediatric Oncology
- Flow Cytometry
Background:
- Monocyte subsets play crucial roles in immune responses.
- Understanding monocyte subset dynamics in pediatric cancers is vital for treatment optimization.
Purpose of the Study:
- To quantify monocyte subsets in newly diagnosed pediatric solid tumors.
- To investigate the association between monocyte subsets and treatment outcomes in pediatric cancer patients.
Main Methods:
- Prospective case-controlled study involving 100 pediatric solid tumor patients and 40 healthy controls.
- Blood samples collected pre-chemotherapy analyzed for monocyte subsets using flow cytometry.
- Routine laboratory tests performed alongside monocyte subset assessment.
Main Results:
- Significant elevations in intermediate and non-classical monocytes were observed in pediatric cancer patients compared to controls.
- Non-classical and intermediate monocytes demonstrated a significant impact on treatment response.
- A positive correlation was found between non-classical monocytes and overall survival (OS).
Conclusions:
- Non-classical and intermediate monocytes are associated with improved treatment response in pediatric solid tumors.
- Non-classical monocytes correlate with higher overall survival.
- Further research is necessary to fully elucidate the functional roles of monocyte subsets in diverse pediatric tumors.
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