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Related Experiment Video

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Appetitive Associative Olfactory Learning in Drosophila Larvae
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Structure-function associations of successful associative encoding.

Nina Becker1, Grégoria Kalpouzos2, Alireza Salami3

  • 1Max Planck Institute for Human Development, Otto Hahn Research Group on Associative Memory in Old Age, Berlin, Germany; Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Neuroimage
|July 20, 2019
PubMed
Summary
This summary is machine-generated.

This study reveals how brain structure and activity link during memory formation. Larger gray matter in the hippocampus correlates with better associative memory, involving the medial-temporal lobe and inferior frontal gyrus.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Functional MRI studies highlight the hippocampus and inferior frontal gyrus (IFG) in associative memory.
  • Structural MRI studies link gray-matter volume in these regions to associative memory.
  • The relationship between brain volume and activity during associative memory formation is not fully understood.

Purpose of the Study:

  • To investigate the association between gray-matter volume and brain activity during associative memory encoding.
  • To explore how medial-temporal lobe (MTL) and IFG structure and function relate during memory formation.

Main Methods:

  • Joint independent component analysis (jICA) was used to analyze T1-weighted and functional MRI data from 27 young adults.
  • Participants underwent intentional encoding of object pairs followed by a recognition task.
  • Voxel-based morphometry was employed for unimodal analysis of gray-matter volume.

Main Results:

  • Better associative memory performance was associated with larger gray-matter volume in the left anterior hippocampus.
  • jICA identified a component linking gray-matter volume in the anterior and posterior MTL with IFG activity during encoding.
  • This suggests that MTL gray matter influences activity in distant parts of the associative memory circuit.

Conclusions:

  • Gray matter volume in the medial-temporal lobe modulates activity in connected brain regions during associative memory encoding.
  • Findings support and extend previous research on functional connectivity between the MTL and IFG in associative memory tasks.