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Published on: September 25, 2009
Aneurysm Formation, Growth, and Rupture: The Biology and Physics of Cerebral Aneurysms
Pavlos Texakalidis1, Ahmad Sweid2, Nikolaos Mouchtouris2
1Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA.
Abstract:
Cerebral aneurysms (CAs) are characterized by a pathological wall structure with internal elastic lamina and media disruption, which leads to focal weakened pouches of the arterial wall. The prevalence of unruptured CAs has been estimated to be 2%-5% in the general population. During the past few decades, the pathophysiological mechanisms behind the formation, growth, and rupture of CAs have been the focus of numerous research studies. In the present review, we have summarized the inflammatory pathways, genetics, and risk factors for the formation, growth, and rupture of CAs. In addition, we have discussed the concepts of geometric indexes, flow patterns, and fluid dynamics that govern CA development.
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