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Association of Mean Platelet Volume with Acute Ischemic Cerebrovascular Accident Among Patients with Type 2 Diabetes
Priyanka Patil1, Arathi Darshan2, Saroja Ao3
1Senior Resident, Department of General Medicine, K.L.E. University's Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi 590003, Karnataka;Corresponding Author.
Objective:
To study the association of MPV (mean platelet volume) and acute ischemic stroke in patients of type 2 diabetes mellitus (DM).
Material:
This was a 1-year cross-sectional hospital-based study involving 79 patients presented with acute ischemic stroke. Among them, 25 were diabetic and 54 were nondiabetic. Demographic data and history of the patients were recorded. Investigations such as haemoglobin estimation, platelet count, MPV, HbA1c, imaging studies were conducted and evaluated for acute ischemic brain stroke. All the patients underwent neurological examination according to National Institute of Health Stroke Scale (NIHSS) at the time of admission and MPV was noted. Outcome of stroke was assessed during discharge by modified Rankin morbidity (MRM) score. SPSS 20 was used to analyse the data.
Results:
Among 79 them, 25 patients (31.6%) had history of diabetes which formed the diabetic subset and the remaining 54 (68.35%) were considered in non-diabetic subset. MPV in patients with DM was significantly high (10.16 ± 0.89 fL) compared to nondiabetic patients (8.25 ± 0.91 fL; p<0.001). The mean NIHSS scores were significantly high in patients with diabetes compared to nondiabetic patients (20.38±3.19 vs. 17.76±3.74; p=0.006). Also, the mean MRM scores were significantly high in diabetics than that of nondiabetics (4.12 ± 0.66 vs. 3.00 ± 0.61; p<0.001). History of stroke was present in 12% of patients with DM compared to 1.85% of the non-diabetic patients (p=0.091).
Conclusion:
Acute ischemic stroke in diabetic patients is significantly associated with raised MPV level, which is likely to be severe with high morbidity and mortality. Hence, MPV is an easily available blood parameter, which defines platelet reactivity and proves to be a good predictor of severity and outcome of stroke in diabetics. Also, higher percentile of patients showed history of recurrent stroke in diabetics as compared to non-diabetics in whom the MPV was considerably raised compared to other diabetic stroke cases.
Insights
Diabetic patients experiencing acute ischemic stroke have significantly higher mean platelet volume (MPV) levels, indicating increased stroke severity and poorer outcomes. MPV serves as a valuable predictor for stroke prognosis in individuals with type 2 diabetes mellitus.
Area of Science:
- Cardiology
- Neurology
- Endocrinology
Background:
- Type 2 diabetes mellitus (DM) is a significant risk factor for cardiovascular diseases, including ischemic stroke.
- Platelet activation and increased platelet volume are implicated in thrombotic events.
Purpose of the Study:
- To investigate the association between mean platelet volume (MPV) and acute ischemic stroke in patients with type 2 DM.
- To evaluate MPV as a potential biomarker for stroke severity and outcome in diabetic patients.
Main Methods:
- A 1-year cross-sectional hospital-based study of 79 acute ischemic stroke patients (25 diabetic, 54 non-diabetic).
- Collected demographic data, medical history, and performed laboratory tests including MPV, HbA1c, and platelet count.
- Assessed stroke severity using the National Institute of Health Stroke Scale (NIHSS) and outcome using the modified Rankin morbidity (MRM) score.
Main Results:
- Diabetic patients exhibited significantly higher MPV levels (10.16 ± 0.89 fL) compared to non-diabetic patients (8.25 ± 0.91 fL; p<0.001).
- Higher mean NIHSS (20.38±3.19 vs. 17.76±3.74; p=0.006) and MRM scores (4.12 ± 0.66 vs. 3.00 ± 0.61; p<0.001) were observed in diabetic patients.
- A higher incidence of prior stroke history was noted in diabetic patients (12%) compared to non-diabetics (1.85%; p=0.091).
Conclusions:
- Elevated MPV is significantly associated with acute ischemic stroke in type 2 DM patients.
- MPV may serve as a readily available predictor of stroke severity, morbidity, and mortality in diabetic individuals.
- Diabetic patients with stroke showed a higher prevalence of recurrent stroke and elevated MPV compared to non-diabetic stroke patients.
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