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Related Experiment Video

Updated: Jan 22, 2026

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

Published on: May 12, 2023

The diverse structural landscape of quadruplexes.

Helen L Lightfoot¹, Timo Hagen¹, Natalie J Tatum²

¹Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland.

|July 21, 2019

Summary

G-quadruplexes are RNA secondary structures with diverse roles in cells and disease. Recent findings reveal unique G-quadruplex structures, expanding therapeutic targeting strategies.

Keywords:

canonical non-canonical nucleic acids quadruplex structure

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Last Updated: Jan 22, 2026

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping

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Published on: May 12, 2023

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

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Published on: September 19, 2017

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Area of Science:

Molecular Biology
Biochemistry
Structural Biology

Background:

G-quadruplexes are G-rich secondary structures in DNA and RNA.
Extensive research has elucidated DNA G-quadruplexes.
RNA G-quadruplexes are increasingly recognized for their in cellulo functions and pathological relevance.

Purpose of the Study:

To review G-quadruplex formation and structure.
To highlight recent discoveries of non-canonical G-quadruplex structures.
To discuss the therapeutic potential of targeting RNA G-quadruplexes.

Main Methods:

Literature review of G-quadruplex research.
Analysis of structural characteristics of G-quadruplexes.
Discussion of emerging detection methods.

Main Results:

G-quadruplexes exhibit diverse structural features beyond canonical forms.
Unique motifs like bulges and long loops expand the known G-quadruplex repertoire.
RNA G-quadruplexes are confirmed to exist and function within cells.

Conclusions:

The structural diversity of G-quadruplexes is greater than previously understood.
Novel G-quadruplex structures offer new avenues for therapeutic intervention.
Advancements in detection methods will further refine our understanding and therapeutic targeting of G-quadruplexes.