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Related Concept Videos

The Electromagnetic Spectrum02:37

The Electromagnetic Spectrum

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The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the various colors of visible light has specific frequencies and wavelengths associated with them, and you can see that visible light makes up only a small portion of the electromagnetic spectrum. Because the technologies developed to work in various parts of the electromagnetic spectrum are different, for reasons of convenience and historical...
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The Electromagnetic Spectrum01:24

The Electromagnetic Spectrum

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Electromagnetic waves are categorized according to their wavelengths and frequencies, giving the electromagnetic spectrum. These waves are classified as radio, infrared, ultraviolet, etc. Radio waves refer to electromagnetic radiation with wavelengths ranging from millimeters to kilometers. Radio waves are commonly used for audio communications (i.e., radios) and typically result from an alternating current in the wires of a broadcast antenna. They cover a broad wavelength range and are used...
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IR Spectrum01:19

IR Spectrum

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When infrared (IR) radiation passes through a molecule, the bonds stretch or bend by absorbing the radiation. This absorption creates the molecule's absorption spectrum, which is the plot of its percentage transmittance versus wavenumber.
Transmittance is defined as the ratio of the radiant power passing through a sample to that from the radiation's source. Multiplying the transmittance by 100 gives the percent transmittance (%T), which varies between 100% (no absorption) and 0%...
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Mass Spectrum01:23

Mass Spectrum

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A mass spectrum is the graphical representation of the relative abundance of the charged fragments in an analyte plotted against their mass-to-charge ratio (m/z). The plot's x-axis represents the ratio of the mass of the charged fragment to the number of charges it carries. The y axis of the plot represents the relative abundance of each charged species. The relative abundance is calculated from the signal intensity of each charged species recorded at the detector. The most intense signal (the...
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UV–Vis Spectrum01:30

UV–Vis Spectrum

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When light passes through a substance, a portion of the light is absorbed while the remaining light is reflected or transmitted. If the molecule absorbs light between the wavelengths of 180–400 nm range, the UV spectrum is obtained, and if it absorbs light in the 400–780 nm wavelength range, the visible spectrum is obtained.     
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Mass Spectrum: Interpretation01:24

Mass Spectrum: Interpretation

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An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
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Cat flu: Broad spectrum polymeric antivirals.

Aleksandra Synowiec1, Irma Gryniuk2, Magdalena Pachota1

  • 1Virogenetics Laboratory of Virology, Malopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7a, 30-387, Krakow, Poland; Microbiology Department, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387, Krakow, Poland.

Antiviral Research
|July 21, 2019
PubMed
Summary
This summary is machine-generated.

Poly(sodium 4-styrenesulfonates) (PSSNa) effectively inhibits feline herpesvirus type 1 (FHV-1) and feline calicivirus (FCV). This polymer shows promise for treating and preventing feline upper respiratory tract disease (URTD) in cats.

Keywords:
AntiviralsCat fluFCVFHV-1Feline calicivirusFeline herpesvirus type 1PSSNaSynthetic polymerspoly(sodium 4-styrenesulfonates)

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Area of Science:

  • Veterinary Virology
  • Polymer Science
  • Antiviral Therapeutics

Background:

  • Feline herpesvirus type 1 (FHV-1) and feline calicivirus (FCV) are primary causes of feline upper respiratory tract disease (URTD).
  • URTD manifests as rhinotracheitis, conjunctivitis, and ulcerations, with secondary infections posing significant risks, especially to vulnerable cats.
  • Current treatments for URTD often focus on supportive care, highlighting the need for effective antiviral agents.

Purpose of the Study:

  • To evaluate the antiviral potency of poly(sodium 4-styrenesulfonates) (PSSNa) for topical application against FHV-1 and FCV.
  • To elucidate the mechanisms of action of PSSNa against these common feline respiratory pathogens.
  • To assess the potential of PSSNa as a therapeutic agent for URTD in cats.

Main Methods:

  • In vitro assessment of PSSNa's antiviral activity against FHV-1 and FCV.
  • Mechanistic studies to determine how PSSNa inhibits viral infection and replication.
  • Evaluation of PSSNa's efficacy in blocking viral interaction with host cells and interfering with viral replication cycles.

Main Results:

  • PSSNa demonstrated potent antiviral activity against both FHV-1 and FCV.
  • Mechanistic studies revealed distinct modes of action: PSSNa directly blocks FHV-1 entry by preventing host cell interaction.
  • Against FCV, PSSNa inhibits viral replication during late stages of the infectious cycle.

Conclusions:

  • PSSNa exhibits broad-spectrum antiviral activity against key feline URTD pathogens.
  • The distinct mechanisms of action suggest PSSNa's versatility in combating viral respiratory infections.
  • PSSNa polymers represent promising candidates for topical treatment and prevention strategies against feline URTD.