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Photoswitchable Silver(I) Complex with Anticancer and Antimicrobial Potential.

Aleksandra Kręcigłowa1, Marta Stolarek-Sipior1,2, Patrycja Jagielska1,2

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Summary
This summary is machine-generated.

This study presents a photoswitchable silver complex with potential for photopharmacology. The trans isomer shows selective toxicity against cancer cells, while the cis isomer demonstrates antifungal properties.

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Area of Science:

  • Inorganic Chemistry
  • Photochemistry
  • Materials Science

Background:

  • Development of photoswitchable compounds for targeted therapies.
  • Exploration of silver(I) complexes in medicinal chemistry.
  • Need for novel agents with selective toxicity and antimicrobial properties.

Purpose of the Study:

  • Synthesize and characterize a photoswitchable silver(I) complex.
  • Evaluate its photoisomerization properties and thermal stability.
  • Assess its selective toxicity and potential therapeutic applications.

Main Methods:

  • Synthesis and characterization of a silver(I) complex with arylazopyrazole ligands.
  • Photoisomerization studies using UV-Vis spectroscopy upon irradiation at 365 nm and 530 nm.
  • In vitro cytotoxicity assays on various cancer and normal cell lines (4T1, NMuMG, PC3, A549, HaCaT).
  • Antimicrobial activity testing against bacteria and fungi (Aspergillus fumigatus).

Main Results:

  • The silver(I) complex exhibited efficient and reversible trans-cis photoisomerization.
  • The cis isomer showed a thermal half-life of 13 days at 37°C.
  • A concentration window (around 18 μM) was found where cis isomer is non-toxic to normal and cancer cells, while the trans isomer is toxic to cancer cells but not normal cells.
  • Trans isomer demonstrated higher toxicity than cisplatin against 4T1 cancer cells.
  • The complex displayed fungistatic activity, with the trans isomer showing potential as an antifungal agent against Aspergillus fumigatus.

Conclusions:

  • The photoswitchable silver(I) complex has potential for photopharmacological applications due to its reversible photoisomerization and selective toxicity.
  • The trans photoisomer exhibits promising selective toxicity against cancer cells, warranting further investigation.
  • The complex demonstrates potential as an antifungal agent, particularly the trans isomer against Aspergillus fumigatus.