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Modeling gaze position-dependent opsoclonus.

Lance M Optican1, Janet C Rucker2, John-Ross Rizzo2

  • 1Laboratory of Sensorimotor Research, NEI, NIH, DHHS, Bethesda, MD, United States.

Progress in Brain Research
|July 22, 2019
PubMed
Summary
This summary is machine-generated.

A new computational model explains gaze-dependent opsoclonus/flutter (O/F), a rare saccadic system disorder. This model incorporates novel inputs to omnipause neurons, accounting for O/F variations seen after concussion.

Keywords:
ModelOpsoclonusSaccadeSmooth pursuit

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Ophthalmology

Background:

  • Opsoclonus/flutter (O/F) is a rare disorder affecting the saccadic eye movement system.
  • Previous models of O/F did not account for gaze-position dependent variations.

Purpose of the Study:

  • To develop a new computational model of the saccadic system capable of explaining gaze-position dependent opsoclonus/flutter.
  • To investigate the neural mechanisms underlying a unique case of O/F following concussion.

Main Methods:

  • Modified a pre-existing saccadic system model by incorporating new inputs to omnipause neurons (OPNs) from the nucleus prepositus hypoglossi and frontal eye fields.
  • Included a simplified pursuit system that inhibits OPNs to account for gaze-dependence during pursuit.
  • The model generates commands for eye position changes.

Main Results:

  • The enhanced model successfully accounts for gaze-position dependent O/F, including postsaccadic ocular flutter and opsoclonus during fixation and pursuit in a specific hemifield.
  • The model demonstrates how position-dependent neuronal inputs to OPNs can create delayed reactivation, leading to gaze-dependence.
  • The pursuit system's inhibition of OPNs provides a mechanism for gaze-dependence during smooth pursuit.

Conclusions:

  • The developed model provides a plausible neural mechanism for gaze-position dependent opsoclonus/flutter.
  • This model advances our understanding of saccadic system disorders and their underlying neural control.
  • The findings highlight the importance of incorporating gaze-position information in models of the saccadic system.