Related Experiment Video

Updated: Jan 21, 2026

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

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Notch signaling in breast cancer: From pathway analysis to therapy

B Madhu Krishna1, Samir Jana1, Jyotsana Singhal1

  • 1Department of Medical Oncology, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA, 91010, USA.

Cancer Letters
|July 22, 2019
PubMed

Insights

The Notch signaling pathway is crucial for cell development but often dysregulated in cancer. This review explores Notch inhibitors as a targeted therapy for breast cancer, highlighting their anti-tumor potential.

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Oncology

Background:

  • The Notch signaling pathway is a conserved mechanism regulating cell differentiation, proliferation, and fate determination.
  • Dysregulation of Notch signaling is implicated in various cancers, contributing to carcinogenesis, angiogenesis, and chemoresistance.
  • Elevated Notch receptors and ligands correlate with cancer progression and reduced patient survival.

Purpose of the Study:

  • To review the role of Notch signaling in breast cancer.
  • To evaluate Notch inhibitors as a therapeutic strategy for breast cancer.
  • To summarize current understanding and recent developments in targeting Notch receptors for breast cancer treatment.

Main Methods:

  • Literature review of existing Notch inhibitory drugs and strategies.
  • Analysis of Notch pathway's role in cancer stem cell renewal, angiogenesis, and chemoresistance.
  • Evaluation of Notch inhibitors' anti-tumor properties in various cancer types and clinical trials.

Main Results:

  • Notch signaling pathway dysregulation contributes to breast cancer development and progression.
  • Notch inhibitors demonstrate anti-tumor properties and are under clinical investigation.
  • Specificity of Notch inhibitors is crucial due to the dual role of Notch receptors (oncogenic or tumor-suppressive).

Conclusions:

  • The Notch signaling pathway presents a promising therapeutic target for breast cancer.
  • Targeted inhibition of oncogenic Notch receptors offers a potential strategy for breast cancer treatment.
  • Further research and clinical trials are necessary to optimize Notch inhibitor therapy for breast cancer.
Keywords:
Breast cancerChemo-resistanceMonoclonal antibodiesNotch receptorγ-secretase inhibitors

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