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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues
Zhiming Cheng1, Wagner O Valença2, Gleiston G Dias2
1Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK.
Abstract:
Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.
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