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A Rapid and Quantitative Fluorimetric Method for Protein-Targeting Small Molecule Drug Screening

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Plazomicin: A New Aminoglycoside.

Louis D Saravolatz^1,2, Gary E Stein³

¹Ascension-St John Hospital, Grosse Pointe Woods, and Wayne State University School of Medicine, East Lansing.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|July 23, 2019

Summary

Plazomicin is a new antibiotic effective against drug-resistant bacteria. It shows comparable efficacy to meropenem for complicated urinary tract infections but has a slightly higher risk of increased serum creatinine.

Keywords:

CRE aminoglycoside plazomicin

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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

Published on: March 3, 2023

Area of Science:

Pharmacology and Infectious Diseases
Antimicrobial Resistance
Drug Development

Background:

Multidrug-resistant Enterobacteriaceae pose a significant threat to public health.
Novel antibiotics are crucial for combating infections caused by these resistant pathogens.
Plazomicin (ACHN-490) is a novel parenteral aminoglycoside developed to address this challenge.

Purpose of the Study:

To review the mode of action, antimicrobial activity, pharmacokinetics, clinical indications, and safety profile of plazomicin.
To discuss the considerations for formulary addition and the place of plazomicin in therapy.
To evaluate plazomicin's efficacy and safety compared to meropenem.

Main Methods:

Literature review of studies on plazomicin.
Comparative analysis of plazomicin and meropenem clinical trial data.
Pharmacokinetic and pharmacodynamic assessments.

Main Results:

Plazomicin demonstrated non-inferiority to meropenem in treating complicated urinary tract infections.
The adverse-event profile was comparable, with a notable increase in serum creatinine in the plazomicin group.
Plazomicin targets multidrug-resistant Enterobacteriaceae.

Conclusions:

Plazomicin is an effective treatment option for complicated urinary tract infections caused by susceptible organisms.
Its safety profile is generally comparable to meropenem, with careful monitoring for renal effects recommended.
Plazomicin represents a valuable addition to the therapeutic arsenal against resistant bacterial infections.