Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Causes of Nonlinearity01:22

Nonlinear Pharmacokinetics: Causes of Nonlinearity

712
Nonlinearity in drug pharmacokinetics is caused by various factors influencing how a drug is absorbed, distributed, metabolized, and excreted. Understanding these nonlinear processes is crucial for predicting drug behavior in the body and optimizing drug dosing regimens.
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
712
Nonlinear Pharmacokinetics: Overview01:19

Nonlinear Pharmacokinetics: Overview

1.1K
Nonlinear or dose-dependent pharmacokinetics is a phenomenon that occurs when the pharmacokinetic parameters of certain drugs deviate from linear pharmacokinetics at higher doses. These drugs do not follow the expected first-order kinetics, where the rate of drug elimination is directly proportional to the drug concentration. Instead, they exhibit a nonlinear relationship, which can be attributed to several factors.
Nonlinearity can arise due to the saturation of plasma protein-binding or...
1.1K
Nursing Implementation01:15

Nursing Implementation

6.0K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
6.0K
Nonlinear Pharmacokinetics: Michaelis-Menten Equation01:18

Nonlinear Pharmacokinetics: Michaelis-Menten Equation

1.0K
The Michaelis–Menten equation is a fundamental model for describing capacity-limited kinetics in drug metabolism. It offers insights into the rate of decline of plasma drug concentration Cp over time, with Vmax and KM as pivotal parameters.
Vmax represents the maximum achievable process rate, while KM, known as the Michaelis constant, signifies the drug concentration at which the process rate reaches half its maximum. This relationship between Vmax, KM, and Cp gives rise to three distinct...
1.0K
Nonlinear Pharmacokinetics: Role of Transporters01:27

Nonlinear Pharmacokinetics: Role of Transporters

286
A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
Polymorphisms occurring in drug transporters can alter...
286
Scatter Plot01:15

Scatter Plot

10.8K
The most common and easiest way to display the relationship between two variables, x and y, is a scatter plot. A scatter plot shows the direction of a relationship between the variables. A clear direction happens when there is either:
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acne Vulgaris: Integrating Pathophysiology with Conventional, Herbal, and Nanocarrier-Based Therapeutic Strategies.

Current pharmaceutical design·2026
Same author

Non-intubated video-assisted thoracic surgery in post-radiotherapy lung cancer: A report of ten cases.

Indian journal of anaesthesia·2026
Same author

Transurethral Ropivacaine (100 mg) Bladder Irrigation Reduces the Incidence of Bladder Discomfort in Transurethral Resection of Bladder Tumor: A Randomized Double-blind Trial.

Annals of African medicine·2026
Same author

Emotional intelligence: An important skill to learn now more than ever.

F1000Research·2026
Same author

Recent Advancements on CAR-T Therapy for the Management of Rheumatoid Arthritis: Mechanisms, Challenges and Clinical Insights.

International journal of rheumatic diseases·2026
Same author

Antioxidant Activity of Stallion Spermatozoa After Cryopreservation with Natural Antioxidant-Supplemented Extenders.

Animals : an open access journal from MDPI·2026

Related Experiment Video

Updated: Jan 21, 2026

Implementation of a Nonlinear Microscope Based on Stimulated Raman Scattering
09:13

Implementation of a Nonlinear Microscope Based on Stimulated Raman Scattering

Published on: July 6, 2019

8.0K

Implementation of a Nonlinear Microscope Based on Stimulated Raman Scattering.

Rajeev Ranjan1, Maurizio Indolfi1, Maria Antonietta Ferrara1

  • 1National Research Council, Institute for Microelectronics and Microsystems, Naples Unit, Italy.

Journal of Visualized Experiments : Jove
|July 23, 2019
PubMed
Summary

Researchers developed a homemade Stimulated Raman Scattering (SRS) microscope for label-free imaging. This implementation enables advanced microscopy techniques for scientific research, offering a valuable tool for the community.

More Related Videos

Stimulated Stokes and Antistokes Raman Scattering in Microspherical Whispering Gallery Mode Resonators
12:21

Stimulated Stokes and Antistokes Raman Scattering in Microspherical Whispering Gallery Mode Resonators

Published on: April 4, 2016

11.7K
Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy
09:57

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

Published on: July 25, 2022

4.5K

Related Experiment Videos

Last Updated: Jan 21, 2026

Implementation of a Nonlinear Microscope Based on Stimulated Raman Scattering
09:13

Implementation of a Nonlinear Microscope Based on Stimulated Raman Scattering

Published on: July 6, 2019

8.0K
Stimulated Stokes and Antistokes Raman Scattering in Microspherical Whispering Gallery Mode Resonators
12:21

Stimulated Stokes and Antistokes Raman Scattering in Microspherical Whispering Gallery Mode Resonators

Published on: April 4, 2016

11.7K
Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy
09:57

Multiplex Chemical Imaging Based on Broadband Stimulated Raman Scattering Microscopy

Published on: July 25, 2022

4.5K

Area of Science:

  • Optical Microscopy
  • Spectroscopy
  • Biomedical Imaging

Background:

  • Stimulated Raman Scattering (SRS) microscopy utilizes near-infrared excitation, sharing properties with multi-photon microscopy.
  • Commercial SRS microscopes are not readily available, necessitating custom-built systems.

Purpose of the Study:

  • To describe the implementation of a Stimulated Raman Scattering (SRS) microscope.
  • To demonstrate the capability of a homemade SRS microscope for label-free imaging.

Main Methods:

  • Adapted commercial laser-scanning microscopes with a non-descanned forward detector, bandpass filters, and a lock-in amplifier (LIA).
  • Utilized overlapped pump and probe laser beams, focused through a microscope objective and scanned across the sample.
  • Collected transmitted pulses, filtered pump light, and measured probe pulses using a photodiode (PD) for SRS signal detection.

Main Results:

  • Successfully implemented and demonstrated a functional SRS microscope.
  • Acquired label-free 2D images of 3 µm polystyrene beads, showcasing the system's imaging capabilities.

Conclusions:

  • The described homemade SRS microscope implementation provides a viable option for researchers.
  • This detailed description can significantly benefit the scientific community interested in advanced label-free imaging techniques.