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Hydrogen Gas from Inflammation Treatment to Cancer Therapy
Ying Wu1, Meng Yuan1, Jibin Song1
1MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry , Fuzhou University , Fuzhou 350116 , P.R. China.
Abstract:
Hydrogen (H2) therapy is a highly promising strategy against several diseases due to its inherent biosafety. However, the current H2 treatment modalities rely predominantly on the systemic administration of the gas, resulting in poor targeting and utilization. Furthermore, although H2 has significant anti-tumor effects, the underlying mechanisms have not yet been elucidated. Due to their ultrasmall size, nanomaterials are highly suitable drug-delivery systems with a myriad of biomedical applications. Nanocarrier-mediated H2 delivery, as well as in situ production of H2 by nanogenerators, can significantly improve targeted accumulation of the gas and accelerate the therapeutic effects. In addition, nanomaterials can be further modified to enhance passive or active accumulation at the target site. In this Perspective, we summarize the mechanism of H2 therapy and describe possibilities for combining H2 therapy with nanomaterials. We also discuss the current challenges of H2 therapy and provide some insights into this burgeoning field.
Insights
Hydrogen (H2) therapy shows promise for disease treatment but lacks targeted delivery. Nanomaterials offer a solution by improving H2 accumulation and therapeutic effects, addressing current limitations.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Therapeutic Delivery Systems
Background:
- Hydrogen (H2) therapy is a safe and promising treatment strategy for various diseases.
- Current H2 administration methods suffer from poor targeting and limited utilization.
- The precise mechanisms of H2's anti-tumor effects require further elucidation.
Purpose of the Study:
- To explore the combination of H2 therapy with nanomaterials for enhanced drug delivery.
- To investigate how nanomaterials can improve targeted H2 accumulation and therapeutic efficacy.
- To summarize H2 therapy mechanisms and discuss future directions in nanomedicine.
Main Methods:
- Review of existing literature on H2 therapy mechanisms and nanomaterial applications.
- Discussion of nanocarrier-mediated H2 delivery strategies.
- Exploration of *in situ* H2 production using nanogenerators.
Main Results:
- Nanomaterials can significantly improve the targeted delivery and utilization of H2.
- Modified nanomaterials can enhance passive or active accumulation at target sites.
- Nanomaterial integration offers potential for accelerated therapeutic effects.
Conclusions:
- Combining H2 therapy with nanomaterials presents a viable strategy to overcome current delivery challenges.
- Nanotechnology can enhance the efficacy of H2 for various diseases, including cancer.
- Further research into nanogenerator-based H2 production and targeted delivery is warranted.
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