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Twin-Screw Extrusion Process to Produce Renewable Fiberboards
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Assessing Particle Segregation Using Near-Infrared Chemical Imaging in Twin Screw Granulation.

Aquino L Mundozah1, Jiankai Yang1, Claire C Tridon2

  • 1Department of Chemical and Biological Engineering, University of Sheffield, Mapping Street, Sheffield S1 3JD, UK.

International Journal of Pharmaceutics
|July 23, 2019
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Summary

Near-infrared chemical imaging (NIR-CI) assessed particle segregation in continuous twin screw granulation (TSG). Findings reveal how shear forces influence de-mixing, offering guidelines for granule content uniformity.

Keywords:
MixingNear-infrared chemical imagingSegregationTwin screw granulation

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Area of Science:

  • Pharmaceutical Technology
  • Chemical Engineering
  • Process Analytical Technology

Background:

  • Particle segregation in twin screw granulation (TSG) impacts granule content uniformity.
  • Understanding machinery configuration effects on segregation is crucial but complex.
  • Near-infrared chemical imaging (NIR-CI) offers potential for in-line granule analysis.

Purpose of the Study:

  • To investigate particle segregation in TSG granules using NIR-CI.
  • To elucidate the relationship between TSG operational parameters and segregation.
  • To develop a predictive approach for granule segregation.

Main Methods:

  • Applied NIR-CI along the TSG barrel length.
  • Varied screw element types and liquid binder viscosity.
  • Utilized regime mapping and a dimensionless mixing number to analyze segregation.

Main Results:

  • Identified a direct correlation between shear-induced dispersion and particle de-mixing.
  • Established fundamental granule segregation mechanisms in TSG.
  • Linked particle segregation behavior to shear forces and granule formation.

Conclusions:

  • NIR-CI is effective for assessing particle segregation in TSG.
  • Shear forces play a key role in de-mixing and content uniformity.
  • The proposed regime mapping provides guidelines for controlling TSG processes.