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Allergic Reactions02:06

Allergic Reactions

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Quinolone Allergy.

Edoabasi U McGee1, Essie Samuel1, Bernadett Boronea1

  • 1School of Pharmacy, Philadelphia College of Osteopathic Medicine, Suwanee, GA 30024, USA.

Pharmacy (Basel, Switzerland)
|July 24, 2019
PubMed
Summary
This summary is machine-generated.

Quinolone antibiotic allergy is rising, though less common than beta-lactams. Diagnosis relies on history and drug provocation tests, with moxifloxacin posing the highest anaphylaxis risk.

Keywords:
allergycross-reactivityfluoroquinoloneshypersensitivityquinolones

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Area of Science:

  • Pharmacology
  • Allergy and Immunology
  • Infectious Diseases

Background:

  • Quinolones are the second most frequent antibiotic class linked to allergic reactions.
  • Data on quinolone allergy, including prevalence and risk factors, remain limited.

Purpose of the Study:

  • To review current evidence on quinolone allergy.
  • To discuss diagnosis, clinical features, cross-reactivity, and management strategies.

Main Methods:

  • Literature review of studies on quinolone-induced allergic reactions.
  • Analysis of diagnostic tools, clinical presentations, and management approaches.

Main Results:

  • Quinolone allergy incidence is increasing, associated with expanded use and moxifloxacin introduction.
  • Patient history is crucial; skin and in vitro tests lack validation.
  • Drug provocation tests are diagnostic but risky; cross-reactivity data are conflicting.
  • Moxifloxacin carries the highest risk for anaphylaxis.

Conclusions:

  • Quinolone allergy requires careful evaluation, with drug provocation tests as the gold standard.
  • Management involves discontinuation and avoidance, with desensitization as an option.
  • Further research is needed to clarify cross-reactivity and improve diagnostic accuracy.