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Related Experiment Video

Updated: Jan 21, 2026

Machine Learning-Based Cough Tone Classification: Diagnostic Exploration of Chronic Obstructive Pulmonary Disease and Respiratory Tract Infections

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Rethinking ME/CFS Diagnostic Reference Intervals via Machine Learning, and the Utility of Activin B for Defining

Brett A Lidbury¹, Badia Kita², Alice M Richardson³

¹National Centre for Epidemiology and Population Health, RSPH, College of Health and Medicine, The Australian National University, Canberra, ACT 2601, Australia. brett.lidbury@anu.edu.au.

Diagnostics (Basel, Switzerland)

|July 24, 2019

Summary

This summary is machine-generated.

Activin B shows potential as a biomarker for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Combining activin B with routine blood tests improves ME/CFS diagnosis and severity prediction.

Keywords:

activin biomarker chronic fatigue syndrome cytokine machine learning myalgic encephalomyelitis pathology reference intervals

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Area of Science:

Biochemistry
Immunology
Clinical Diagnostics

Background:

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling condition with an unclear cause.
Biomarker discovery is crucial for laboratory diagnosis of ME/CFS.
Activin B has emerged as a potential quantitative serum marker.

Purpose of the Study:

To investigate serum activin B as a biomarker for ME/CFS.
To assess activin B alone and in combination with routine pathology markers.
To evaluate activin B's utility in predicting ME/CFS severity.

Main Methods:

Serum activin B levels were measured in ME/CFS and control cohorts.
Random Forest (RF) modeling was used to analyze routine blood tests and activin B.
Participants were assessed using Canadian/International Consensus Criteria and weighted standing time (WST).

Main Results:

Conflicting results for serum activin B levels were observed between pilot and current cohorts, with lower median levels in the current ME/CFS cohort.
Five routine pathology markers predicted ME/CFS with ≥62% accuracy.
Inclusion of activin B improved prediction for mild to moderate ME/CFS cases.
24-h urinary creatinine clearance, serum urea, and serum activin B showed diagnostic potential.

Conclusions:

Serum activin B, alongside routine pathology markers like 24-h urinary creatinine clearance and serum urea, holds potential for ME/CFS diagnosis.
Activin B enhances the prediction of ME/CFS symptom severity.
Further validation is needed to establish activin B as a reliable diagnostic and prognostic marker for ME/CFS.