Thromboelastography-guided transfusion in dogs with hypocoagulable disorders: a case series

Area of Science:

• Veterinary Medicine
• Hemostasis and Thrombosis
• Diagnostic Assays

Background:

• Thromboelastography (TEG) is a comprehensive assay analyzing whole blood hemostasis, including plasma and cellular components.
• In human medicine, TEG is utilized therapeutically to assess transfusion therapy efficacy in vitro.
• This case series explores TEG's application in guiding transfusion therapy for canine hypocoagulable disorders.

Observation:

• Four dogs with distinct hypocoagulable disorders were studied: rodenticide intoxication, angiostrongylosis, disseminated intravascular coagulation, and immune-mediated thrombocytopenia.
• TEG served dual roles: diagnosing hemostatic abnormalities and guiding fresh frozen plasma transfusion decisions.
• The study evaluated the necessity and optimal dosage of fresh frozen plasma based on TEG results.

Findings:

• TEG provided valuable insights into the dynamics of clot formation, stabilization, and lysis in affected dogs.
• The assay facilitated informed decisions regarding the initiation and extent of fresh frozen plasma therapy.
• Individualized transfusion protocols were developed based on TEG findings for each canine patient.

Implications:

• TEG can be effectively implemented in veterinary critical care settings.
• This assay enables tailored transfusion strategies for critically ill dogs with hypocoagulable conditions.
• Utilizing TEG may enhance the management and improve the prognosis of dogs with complex hemostatic disorders.