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Related Concept Videos

Phase Transitions02:31

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Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
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Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
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A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
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The Transition Trajectory for the Patient with a Traumatic Brain Injury.

Ava M Puccio1, Maighdlin W Anderson2, Anita Fetzick1

  • 1Department of Neurological Surgery, Neurotrauma Clinical Trials Center, University of Pittsburgh, 200 Lothrop Street, Suite B-400, Pittsburgh, PA 15213, USA.

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Summary
This summary is machine-generated.

This study examines patient outcomes following mild, moderate, and severe traumatic brain injury (TBI). It covers emergency care, acute treatment, discharge, and special considerations for older adults and TBI complications.

Keywords:
Acute careComplicationsDischarge statusOutcomeTraumatic brain injury

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Area of Science:

  • Neuroscience
  • Trauma Care
  • Geriatrics

Background:

  • Traumatic brain injury (TBI) presents a significant public health challenge.
  • Patient trajectories vary widely based on injury severity.
  • Understanding these trajectories is crucial for effective management.

Purpose of the Study:

  • To delineate the patient journey from emergency presentation through acute care and discharge.
  • To identify key factors influencing outcomes in mild, moderate, and severe TBI.
  • To address specific challenges in the elderly population and common TBI complications.

Main Methods:

  • Retrospective review of patient data.
  • Analysis of clinical pathways for different TBI severity levels.
  • Inclusion of data on elderly patients and complication monitoring.

Main Results:

  • Detailed description of patient flow through emergency, acute, and discharge phases.
  • Identification of common complications in severe TBI.
  • Specific considerations for elderly patients highlighted.

Conclusions:

  • Effective management of TBI requires a comprehensive understanding of the entire patient care continuum.
  • Early identification and management of complications are vital, especially in severe TBI and elderly patients.
  • Further research can refine care pathways for improved TBI outcomes.