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Autophosphorylation activates c-Src kinase through global structural rearrangements.

Edgar E Boczek1, Qi Luo2, Marco Dehling3

  • 1Center for Integrated Protein Science, Department Chemie, Technische Universität München, 85748 Garching, Germany; Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany.

The Journal of Biological Chemistry
|July 24, 2019
PubMed
Summary

Autophosphorylation of c-Src kinase stabilizes the ATP binding site, increasing enzymatic activity. This process involves domain rearrangements and increased kinase domain rigidity for signal transduction.

Keywords:
ATPSrcactivationbiophysicsconformational changeenzyme mechanismhydrogen/deuterium exchangemolecular dynamicsoncogenephosphorylationprotein kinase

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