Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Example: Aggregate Gradation01:24

Design Example: Aggregate Gradation

319
The right type and quality of aggregates are crucial for concrete as they significantly influence its properties, mix proportions, and cost-effectiveness. If different sources are available for sand, the commonly used fine aggregate in concrete, the selection of sand is primarily based on its gradation.
The grading, or particle-size distribution, of sand is determined using sieve analysis, with standard sizes ranging from 150 μm to 10 mm (ASTM No. 100 sieve to 3⁄8 in. sieve). Sand is...
319
Experimental Designs01:16

Experimental Designs

16.7K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
16.7K
Design Example: Traverse Angle Computations01:25

Design Example: Traverse Angle Computations

311
Traverse angle computations are a critical component of surveying, used to compute the internal angles within a closed traverse. A traverse consists of a series of connected lines forming a closed loop, often used for land boundary delineation or mapping. Calculating the internal angles ensures accuracy in the traverse geometry and is essential for checking survey data integrity.The process begins with known azimuths and bearings of the traverse sides. Internal angles at each vertex are...
311
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

270
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
270
Group Design02:01

Group Design

10.3K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
10.3K
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

241
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
241

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

pH-responsive folate-targeted catalase conjugate for enhanced cellular uptake and oxidative stress protection in triple-negative breast cancer.

European journal of pharmacology·2026
Same author

Recent advances in the delivery of natural-product antioxidants for the treatment of breast cancer.

Frontiers in bioengineering and biotechnology·2026
Same author

Influence of pH on the cytotoxic activity of organic acids against breast cancer cells.

Bioorganic & medicinal chemistry·2025
Same author

Hydrogel-based microneedles for the delivery of catalase protein.

International journal of pharmaceutics·2025
Same author

Inhibition of the Early-Stage Cross-Amyloid Aggregation of Amyloid-β and IAPP via EGCG: Insights from Molecular Dynamics Simulations.

ACS omega·2024
Same author

3D-Printed Microcubes for Catalase Drug Delivery.

ACS omega·2023

Related Experiment Video

Updated: Jan 21, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

986

Computational and Experimental Approaches to Design Inhibitors of Amylin Aggregation.

Ammu Prasanna Kumar1,2, Sungmun Lee3, Suryani Lukman1

  • 1Department of Chemistry, College of Arts and Sciences, Khalifa University, Abu Dhabi, United Arab Emirates.

Current Drug Targets
|July 24, 2019
PubMed
Summary

Amylin aggregation is toxic in type 2 diabetes. This review explores amylin structure, inhibitors, and its role in obesity and Alzheimer's disease for novel therapeutic strategies.

Keywords:
Alzheimer's disease therapyAmylinIAPPaggregation inhibitorsconformation of amylinislet amyloid polypeptideliterature reviewtype 2 diabetes therapy.

More Related Videos

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.8K
Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

3.8K

Related Experiment Videos

Last Updated: Jan 21, 2026

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

986
Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.8K
Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

3.8K

Area of Science:

  • Biochemistry
  • Endocrinology
  • Neuroscience

Background:

  • Amylin, secreted by pancreatic ß-cells, aggregates and becomes toxic in type 2 diabetes mellitus (T2DM).
  • Understanding amylin's structure and aggregation is crucial for developing drugs to inhibit this process.
  • Amylin also plays a role in obesity and Alzheimer's disease (AD).

Purpose of the Study:

  • To review experimental and computational studies on amylin structures and inhibitors.
  • To provide insights for designing effective amylin aggregation inhibitors for T2DM.
  • To explore the potential of targeting amylin aggregation for obesity and AD therapeutics.

Main Methods:

  • Literature review of experimental and computational studies on amylin.
  • Text-mining over 3,000 PubMed abstracts for amylin-related information.
  • Analysis of existing data on amylin inhibitors and their mechanisms.

Main Results:

  • Identified key structural features and aggregation mechanisms of amylin.
  • Detailed various classes of amylin inhibitors (small molecules, proteins, peptides, metal ions).
  • Highlighted the importance of considering physiological conditions (e.g., membranes) in inhibitor studies.
  • Text-mining suggested therapeutic potential of combining amylin strategies with leptin and GLP-1 for obesity.

Conclusions:

  • Targeting amylin aggregation offers a promising therapeutic avenue for T2DM, obesity, and AD.
  • Designing effective inhibitors requires considering amylin's diverse attributes and physiological context.
  • Further research into amylin-inhibitor complexes under relevant conditions is needed.