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3D-Printed Microcubes for Catalase Drug Delivery.

Sungmun Lee1,2, Dong-Wook Lee3, Nitul Rajput3

  • 1Department of Biomedical Engineering, Khalifa University of Science and Technology, Abu Dhabi 127788, UAE.

ACS Omega
|August 7, 2023
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Summary

Three-dimensional printed microcubes efficiently deliver catalase, an antioxidant enzyme, protecting cells from oxidative stress. These uniform microparticles show promise for therapeutic protein delivery.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Oxidative stress from reactive oxygen species (ROS) contributes to inflammatory diseases.
  • Catalase, an antioxidant enzyme, has therapeutic potential but faces delivery challenges.
  • Uniform, small drug delivery vehicles are crucial for efficient therapeutic protein delivery.

Purpose of the Study:

  • To investigate 3D-printed microcubes as drug delivery vehicles for catalase.
  • To assess the characteristics of 3D-printed microcubes for targeted delivery.
  • To evaluate the efficacy of catalase-loaded microcubes.

Main Methods:

  • High-resolution 3D printing (Nanoscribe Photonic Professional GT2) to create microcubes.
  • Loading catalase onto microcubes via nonspecific adsorption.
  • Assessing catalase activity and protective effects on macrophages (RAW 264.7) against hydrogen peroxide (H₂O₂).

Main Results:

  • 3D-printed microcubes (800 nm x 600 nm) are suitable for passive macrophage targeting.
  • Catalase-loaded microcubes (CAT-MC) retained 83.1% of intact catalase activity.
  • CAT-MC protected macrophages from H₂O₂-induced cytotoxicity by 86.4%.

Conclusions:

  • 3D-printed microparticles offer tunable size and shape for consistent drug distribution and activity.
  • These microparticles are highly promising for delivering therapeutic proteins.
  • Potential for broad applications in treating inflammatory diseases.