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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
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Subcutaneous vaccination using injectable biodegradable hydrogels for long-term immune response.

Ashlynn L Z Lee1, Chuan Yang1, Shujun Gao1

  • 1Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.

Nanomedicine : Nanotechnology, Biology, and Medicine
|July 24, 2019
PubMed
Summary

This study introduces a Vitamin E-PEG-Vitamin E hydrogel for sustained vaccine delivery, enhancing long-term anticancer immunity and improving survival rates in mouse models with no observed adverse effects.

Keywords:
Hepatitis BImmunizationInjectable hydrogelOvalbuminVaccine

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Area of Science:

  • Biomaterials Science
  • Immunology
  • Cancer Research

Background:

  • Prolonged vaccine release is crucial for sustained immunostimulation and long-term immunity.
  • Existing vaccine delivery systems often lack the capacity for extended drug release.
  • Developing advanced delivery platforms is essential for effective cancer prevention and treatment.

Purpose of the Study:

  • To develop and evaluate a novel Vitamin E-PEG-Vitamin E triblock hydrogel for sustained delivery of cancer preventive vaccines.
  • To assess the hydrogel's ability to enhance anticancer immunity and therapeutic outcomes in preclinical models.
  • To determine the safety profile of the hydrogel formulation in vivo.

Main Methods:

  • Fabrication of a Vitamin E-PEG-Vitamin E 'ABA' hydrogel via physical cross-linking of flower-shaped micelles.
  • In vivo evaluation of hydrogel residence time (>17 weeks).
  • Assessment of antibody production, tumor rejection (EG.7-OVA model), and survival rates (lymphoma metastasis model) in vaccinated mice.

Main Results:

  • Hydrogel formulations significantly increased antibody production compared to solution formulations.
  • OVA-loaded hydrogel with aluminum adjuvant demonstrated superior therapeutic efficacy, significantly reducing tumor size and incidence.
  • The hydrogel formulation showed no adverse effects on liver and kidney function.
  • Vaccination with OVA-loaded hydrogel and adjuvant increased survival to 66.7% in a lymphoma metastasis model.

Conclusions:

  • The Vitamin E-PEG-Vitamin E hydrogel is a promising biomaterial for sustained vaccine delivery.
  • This formulation effectively enhances anticancer immunity and therapeutic outcomes.
  • The hydrogel offers a safe and effective platform for developing long-term cancer preventive vaccines.