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Related Experiment Videos

Pentose pathway in human liver.

I Magnusson1, V Chandramouli, W C Schumann

  • 1Department of Clinical Physiology, Karolinska Institute at Huddinge Hospital, Stockholm, Sweden.

Proceedings of the National Academy of Sciences of the United States of America
|July 1, 1988
PubMed
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Glucuronide conjugates of drugs can noninvasively sample hepatic glucose 6-phosphate. This study confirms the classical pentose pathway is active in human liver, not the L-type pathway.

Area of Science:

  • Biochemistry
  • Metabolic pathways
  • Pharmacology

Background:

  • Drugs like diflunisal and acetaminophen are excreted as glucuronides.
  • Understanding the metabolic fate of glucose in the liver is crucial for various physiological and pathological conditions.

Purpose of the Study:

  • To investigate if urinary glucuronides can serve as a noninvasive method to analyze hepatic glucose metabolism.
  • To determine the predominant glucose metabolic pathway in human liver.

Main Methods:

  • Administration of [1-14C]ribose and [2-14C]glucose to normal subjects.
  • Measurement of 14C distribution in excreted glucuronides and blood glucose.
  • Analysis of hepatic glucose 6-phosphate pool composition.

Main Results:

Related Experiment Videos

  • 14C from [1-14C]ribose predominantly incorporated into carbons 1 and 3 of glucuronic acid.
  • 14C from [2-14C]glucose showed high labeling in carbon 2 of glucuronic acid.
  • These findings support glucuronides sampling the glucose unit of the glucose 6-phosphate pool.

Conclusions:

  • Urinary glucuronic acid conjugates of drugs can be used as a noninvasive tool to sample hepatic glucose 6-phosphate.
  • The classical pentose pathway, not the L-type pathway, is the primary route for glucose metabolism in human liver.
  • Only a small fraction of glucose is metabolized through the pentose pathway in the liver.