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Updated: Jan 21, 2026

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
Electrochemical Sensing of α-Fetoprotein Based on Molecularly Imprinted Polymerized Ionic Liquid Film on a Gold
Yingying Wu1,2, Yanying Wang2, Xing Wang2
1Institute of Food Science and Engineering Technology, Hezhou University, Hezhou 542899, China.
Abstract:
A molecularly imprinted sensor was fabricated for alpha-fetoprotein (AFP) using an ionic liquid as a functional monomer. Ionic liquid possesses many excellent characteristics which can improve the sensing performances of the imprinted electrochemical sensor. To demonstrate this purpose, 1-[3-(N-cystamine)propyl]-3-vinylimidazolium tetrafluoroborate ionic liquid [(Cys)VIMBF4] was synthesized and used as a functional monomer to fabricate an AFP imprinted polymerized ionic liquid film on a gold nanoparticle modified glassy carbon electrode (GCE) surface at room temperature. After removing the AFP template, a molecularly imprinted electrochemical sensor was successfully prepared. The molecularly imprinted sensor exhibits excellent selectivity towards AFP, and can be used for sensitive determination of AFP. Under the optimized conditions, the imprinted sensor shows a good linear response to AFP in the concentration range of 0.03 ng mL-1~5 ng mL-1. The detection limit is estimated to be 2 pg mL-1.
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