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Related Experiment Video

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Echo Particle Image Velocimetry
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Transverse relaxometry with transmit field-constrained stimulated echo compensation.

Reza Basiri1,2,3, Paolo Federico4,5,6,7, Robert Marc Lebel8,6,9,7

  • 1Biomedical Engineering, University of Calgary, 2500 University Dr NW, Calgary, AB, T2N 1N4, Canada. rbasiri@ucalgary.ca.

Magma (New York, N.Y.)
|July 25, 2019
PubMed
Summary

A new two-step stimulated echo correction (SEC) method improves T2 mapping accuracy and precision by reducing fitting parameters. This technique offers more reliable quantitative T2 maps for relaxometry studies.

Keywords:
Extended phase graphMagnetic resonance imagingRelaxometrySpin echo imagingStimulated echo correction

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Area of Science:

  • Magnetic Resonance Imaging
  • Quantitative Imaging
  • Biomedical Engineering

Background:

  • Conventional T2 mapping often deviates from pure exponential decay due to factors like transmit field inhomogeneity.
  • Stimulated Echo Correction (SEC) can improve accuracy but introduces extra fitting parameters, increasing uncertainty.
  • Existing methods struggle with precise and accurate T2 quantification.

Purpose of the Study:

  • To develop a more accurate and precise method for T2 mapping using stimulated echo correction.
  • To reduce the uncertainty associated with T2 quantification in MRI.

Main Methods:

  • Introduced a novel two-step SEC (tSEC) method for T2 mapping.
  • tSEC leverages spatial correlations in the transmit field to decrease fitting parameters from three to two.
  • Employs a two-pass fitting process, including a smoothed transmit field estimation.

Main Results:

  • Demonstrated significant reductions in relative T2 variance (up to 38% in simulations, 27% in vivo) compared to standard SEC.
  • Average T2 values remained consistent between tSEC and SEC.
  • The tSEC method is compatible with existing data and requires the same input as standard exponential and SEC fits.

Conclusions:

  • The tSEC method provides reliable and reproducible quantitative T2 maps.
  • This approach should be considered for future relaxometry studies requiring precise T2 quantification.