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A Multi-Perspective Review on Dengue Research.

M Elizabeth Sobhia1, Ketan Ghosh1, Ajeet Singh1

  • 1Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research, Mohali, India.

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Summary

Dengue fever, a mosquito-borne viral illness, lacks effective treatments. This review explores natural compounds and drug candidates, offering hope for new dengue fever therapies.

Keywords:
Dengue transmissionclinical studiesin silico worknon structural proteinspatentprotein data bankstructural proteins.

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Area of Science:

  • Virology
  • Tropical Medicine
  • Pharmacology

Background:

  • Dengue fever is a significant global health concern, endemic in over 100 countries and transmitted by Aedes mosquitoes.
  • Current dengue fever management primarily focuses on symptomatic relief, with limited antiviral or vaccine options available.
  • Natural remedies like Carica papaya leaf extract are used, but scientific validation and standardized treatments are lacking.

Purpose of the Study:

  • To review the current global situation of dengue fever.
  • To highlight the potential of natural chemical compounds and drug candidates for dengue fever treatment.
  • To analyze drug targets and recent patents related to dengue fever therapeutics.

Main Methods:

  • Literature review of dengue fever epidemiology and current treatments.
  • Structure-Activity Relationship (SAR) studies to identify active natural moieties.
  • Analysis of clinical trial drug candidates and relevant patents.
  • Protein Data Bank (PDB) analysis for potential therapeutic protein targets.

Main Results:

  • Identified natural chemical moieties, such as methionine-proline anilides and tetrapeptide aldehyde, with potential antiviral activity.
  • Reviewed promising drug candidates currently in clinical trials for dengue fever.
  • Outlined significant patents in dengue fever drug development over the last two decades.
  • Analyzed potential protein targets in the Protein Data Bank crucial for dengue virus replication.

Conclusions:

  • Natural chemical moieties and emerging drug candidates show promise for novel dengue fever treatments.
  • Further research into identified targets and compounds could lead to effective antiviral therapies.
  • The review provides a comprehensive overview of recent advancements and future directions in dengue fever drug discovery.