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Updated: Jan 21, 2026
08:51
Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
Published on: November 1, 2019
6.0K
Single-subject structural cortical networks in clinically isolated syndrome.
Sara Collorone1, Ferran Prados2, Marloes Hj Hagens3
1NMR Research Unit, Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 25, 2019
Summary
Structural cortical networks (SCNs) reveal significant disruptions in patients with clinically isolated syndrome (CIS). These brain network changes correlate with disease severity and cognitive impairment, highlighting SCNs as a valuable biomarker.
Area of Science:
- Neuroimaging
- Brain Network Analysis
- Clinical Neurology
Background:
- Structural cortical networks (SCNs) capture coordinated morphological changes in the brain.
- SCNs can be derived from existing clinical MRI scans.
- Pathophysiological changes in SCNs are observed in various neurological disorders, including multiple sclerosis.
Purpose of the Study:
- To investigate individual-level alterations in SCNs among patients diagnosed with clinically isolated syndrome (CIS).
- To assess the clinical relevance of these SCN alterations in CIS patients.
Main Methods:
- Analysis of baseline data from a prospective, multicenter MAGNIMS study.
- Inclusion of 60 CIS patients and 38 healthy controls who underwent high-resolution 3T MRI.
- Extraction of single-subject SCNs from 3D-T1 weighted MRI sequences and computation of global and local network parameters.
Main Results:
- CIS patients exhibited altered small-world topology compared to healthy controls.
- Disruptions in network organization were more pronounced in CIS patients with higher lesion load and slower cognitive processing speed.
- Specific cortical areas showed altered centrality measures and connection clustering in CIS patients.
Conclusions:
- SCNs effectively demonstrate clinically relevant alterations in brain connectivity within CIS patients.
- SCNs show potential as a biomarker for assessing neurological changes in early-stage multiple sclerosis.
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