Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Arteries of the Head and Neck01:26

Arteries of the Head and Neck

3.1K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
3.1K
Veins of Head and Neck01:19

Veins of Head and Neck

5.3K
The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
5.3K
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

4.8K
The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
4.8K
The Spindle Assembly Checkpoint02:19

The Spindle Assembly Checkpoint

3.7K
The spindle assembly checkpoint is a molecular surveillance mechanism ensuring the fidelity of chromosome segregation during anaphase. The checkpoint monitors the completion of all the prerequisite steps before chromosome segregation to determine whether the segregation process should proceed or be delayed.
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
3.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Muscles of the Anterior Neck01:26

Muscles of the Anterior Neck

4.6K
The anterior neck muscles are the group of muscles covering the front part of the neck. These muscles are classified into three subgroups. The first one is the superficial muscles, the most visible muscles in the front of the neck. It includes the platysma and sternocleidomastoid. The second group is the suprahyoid muscles, located above the hyoid bone. This group comprises the digastric, mylohyoid, geniohyoid, and stylohyoid. Lastly, the infrahyoid muscles are found below the hyoid bone and...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ret Signaling Is Required for Tooth Pulp Innervation during Organogenesis.

Journal of dental research·2019
Same author

Histologic pattern of invasion and epithelial-mesenchymal phenotype predict prognosis in squamous carcinoma of the head and neck.

Oral oncology·2018
Same author

Structural, electronic, and magnetic properties of tris(8-hydroxyquinoline)iron(III) molecules and their magnetic coupling with ferromagnetic surface: first-principles study.

Journal of physics. Condensed matter : an Institute of Physics journal·2016
Same author

Long non-coding RNA C2dat1 regulates CaMKIIδ expression to promote neuronal survival through the NF-κB signaling pathway following cerebral ischemia.

Cell death & disease·2016
Same author

A post-GWAS confirming the SCD gene associated with milk medium- and long-chain unsaturated fatty acids in Chinese Holstein population.

Animal genetics·2016
Same author

Vascular risk factors aggravate cognitive impairment in first-ever young ischaemic stroke patients.

European journal of neurology·2016
Same journal

Gold Nanoparticles Enhance the Antibacterial and Osteogenic Properties of Polyetheretherketone.

Journal of dental research·2026
Same journal

Periodontitis-Aggravated Diabetic Kidney Disease with Altered Glycolysis.

Journal of dental research·2026
Same journal

Response to Letter to Editor: "Estimating the Individualized Effect of Tooth Extraction before Radiotherapy on Osteoradionecrosis Using Causal Machine Learning".

Journal of dental research·2026
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Jan 21, 2026

Porcine As a Training Module for Head and Neck Microvascular Reconstruction
07:43

Porcine As a Training Module for Head and Neck Microvascular Reconstruction

Published on: September 29, 2018

8.1K

Head and Neck Cancer Immunotherapy beyond the Checkpoint Blockade.

B R Heath1,2, N L Michmerhuizen3,4, C R Donnelly1

  • 11 Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.

Journal of Dental Research
|July 26, 2019
PubMed
Summary
This summary is machine-generated.

Overcoming resistance to immunotherapy in head and neck squamous cell carcinoma (HNSCC) is crucial. Targeting oncogenes that suppress immune sensing alongside checkpoint blockade may prime the immune system and improve treatment responses.

Keywords:
cancer vaccinesglycolysishead and neck cancerimmunotherapyinnate immunitytype I interferon

More Related Videos

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System
05:45

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

Published on: January 9, 2020

8.4K
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

11.3K

Related Experiment Videos

Last Updated: Jan 21, 2026

Porcine As a Training Module for Head and Neck Microvascular Reconstruction
07:43

Porcine As a Training Module for Head and Neck Microvascular Reconstruction

Published on: September 29, 2018

8.1K
In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System
05:45

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System

Published on: January 9, 2020

8.4K
A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

11.3K

Area of Science:

  • Oncology
  • Immunology
  • Cancer Genomics

Background:

  • Immune checkpoint blockade shows promise for head and neck squamous cell carcinoma (HNSCC) treatment.
  • However, fewer than 15% of HNSCC patients respond, highlighting significant resistance.
  • Genomic alterations in HNSCC can suppress immune sensing, impacting both innate and adaptive immunity.

Purpose of the Study:

  • To review recent advances in identifying HNSCC oncogenes that impair anti-tumor immunity.
  • To discuss emerging immune-priming strategies to sensitize HNSCC to checkpoint blockade.
  • To explore novel therapeutic approaches for improving immunotherapy response rates in HNSCC.

Main Methods:

  • Literature review of recent advances in HNSCC immunotherapy resistance.
  • Analysis of oncogenic mechanisms suppressing immune sensing in HNSCC.
  • Exploration of immune-priming strategies including cancer vaccines, radiation, DNA damage agents, and metabolic reprogramming.

Main Results:

  • Key HNSCC oncogenes have been identified that inhibit innate and adaptive anti-tumor immune responses.
  • Immune-priming strategies aim to enhance T-cell expansion, overcome immune tolerance, and support T-cell activation.
  • Novel approaches like type I interferon agonists, radiation, and metabolic reprogramming show potential for sensitizing HNSCC to immunotherapy.

Conclusions:

  • Targeting oncogenic inhibition of immune sensing is a promising strategy to improve HNSCC immunotherapy.
  • Multifaceted approaches are needed to expand the pool of responders to checkpoint blockade in HNSCC.
  • Further research into HNSCC immune regulators, improved mouse models, and adjuvant delivery systems is essential for clinical translation.