Related Experiment Video
Updated: Jan 21, 2026

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients
Published on: March 1, 2024
CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population
Hanna Lesiewska1, Katarzyna Linkowska2, Joanna Stafiej1
1Department of Ophthalmology, The Nicolaus Copernicus University, Ludwik Rydygier's Collegium Medicum in Bydgoszcz, Skłodowskiej Curie 9, 85-094 Bydgoszcz, Poland.
Purpose:
To evaluate CLU polymorphisms in patients with pseudoexfoliation syndrome.
Materials And Methods:
We studied 81 patients (23 males and 58 females, the median age 76 years) and 91 control subjects (27 males and 64 females, the median age 75 years). Genotypes of the CLU polymorphisms (SNPs), rs3087554 and rs2279590, were determined using a commercially available validated genotyping assays. The χ 2 test was performed to compare patient and control groups for possible associations between SNP genotype/allele frequency and disease state.
Results:
There were no significant differences for both allele and genotype frequencies between PEX patients and controls for rs3087554 and rs2279590 polymorphisms. The haplotypes distribution shows statistically significant difference between groups (p=0.03). The haplotype (CT) more often was found in controls than in PEX patients, conferring an 18-fold decreased risk to the disease.
Conclusion:
Our results indicate that CLU variants may contribute to the risk of PEX in the Polish population.
More Related Videos
Related Concept Videos
Conservation of Small Populations
What is Population Genetics?
Population Growth
Single Nucleotide Polymorphisms-SNPs
What are Populations and Communities?
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

