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Updated: Jan 21, 2026

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
Published on: July 30, 2020
A supersensitive biosensor based on MoS2 nanosheet arrays for the real-time detection of H2O2 secreted from living
Huitong Du1, Xinyue Zhang1, Zhe Liu1
1College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China. fengliquhn@hotmail.com.
Abstract:
The fast and accurate real-time monitoring of hydrogen peroxide (H2O2) secreted from living cells plays a critical role in clinical diagnosis and management. Herein, we report low-cost and self-supported MoS2 nanosheet arrays for non-enzymatic eletrochemical H2O2 detection. Under the optimal test conditions, such MoS2 electrodes exhibit extremely promising electrocatalytic performance with a low detection limit of 1.0 μM (S/N = 3) and an excellent sensitivity of 5.3 mA mM-1 cm-2. Furthermore, the detection of the trace amount of H2O2 secreted from live A549 cancer cells was successfully performed with this biosensor.
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