Related Experiment Video

Updated: Jan 21, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.6K

H3K27 trimethylation loss in malignant peripheral nerve sheath tumor: a systematic review and meta-analysis with

Victor M Lu1, Tomas Marek2, Hannah E Gilder2

  • 1Department of Neurosurgery, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA. lu.victor@mayo.edu.au.

Journal of Neuro-Oncology
|July 26, 2019
PubMed
Abstract

Insights

Loss of histone H3K27me3 trimethylation is common in malignant peripheral nerve sheath tumors (MPNSTs). This finding is infrequent in MPNST mimics, suggesting diagnostic potential for H3K27me3 loss in MPNSTs.

Area of Science:

  • Oncology
  • Epigenetics
  • Tumor Biology

Background:

  • Loss of histone 3 trimethylation at lysine 27 (H3K27me3) is frequently observed in high-grade malignant peripheral nerve sheath tumors (MPNSTs).
  • The diagnostic utility of H3K27me3 loss in MPNSTs requires further validation.
  • This study aimed to systematically review and pool existing data on the incidence of H3K27me3 loss in MPNSTs.

Purpose of the Study:

  • To determine the incidence of H3K27me3 loss in high-grade MPNSTs.
  • To assess the specificity of H3K27me3 loss in MPNST-mimicking conditions.
  • To evaluate the diagnostic potential of H3K27me3 loss as a biomarker for MPNSTs.

Main Methods:

  • A systematic literature search was conducted across 7 electronic databases adhering to PRISMA guidelines.
  • Articles were screened based on predefined inclusion and exclusion criteria.
  • A random-effects meta-analysis of proportions was employed to pool the incidence data.

Main Results:

  • Nine studies comprising 823 high-grade MPNST samples were analyzed.
  • The pooled incidence of complete H3K27me3 loss in MPNSTs was 53% (95% CI 42-64%).
  • Incidence of complete H3K27me3 loss varied by MPNST subtype: NF1 (52%), sporadic (53%), epithelioid (0%), and radiation-associated (98%).
  • The incidence of incomplete H3K27me3 loss in 1231 MPNST-mimic samples was 96% (95% CI 90-99%), indicating high specificity.

Conclusions:

  • Substantial incidence of complete H3K27me3 loss in high-grade MPNSTs supports its potential as a diagnostic marker.
  • Low incidence of H3K27me3 loss in MPNST mimics suggests high specificity.
  • Further cohort studies and biological investigations are needed to confirm these findings and elucidate their clinical significance.
Keywords:
H3K27me3LysineMPNSTMalignant peripheral nerve sheath tumorSensitivityTrimethylation

More Related Videos

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

2.1K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.6K

Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
5.9K
Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
5.2K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
367
Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.3K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K
Line Loss01:10

Line Loss

The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
517