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Related Concept Videos

Difference from Background: Limit of Detection01:05

Difference from Background: Limit of Detection

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The limit of detection (LOD) is the smallest amount of analyte that can be distinguished from the background noise. The LOD value corresponds to the concentration at which the analyte signal is three times larger than the standard deviation of the blank signal. Below this value, the analyte signal cannot be differentiated from the background noise. It is calculated by dividing the calibration slope by 3 times the standard deviation of the blank signals.
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A displacement current is analogous to a real current in Ampère's law, participating in Ampère's law the same way as the usual conduction current. However, it is produced by a changing electric field. Displacement current is defined in terms of a time-varying electric field, and also has an associated displacement current density. By adding a term accounting for displacement current, Maxwell modified the existing Ampère's law, which is now called generalized Ampère's law.
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[Prevention of measles outbreak in National Orphans House. Published in Revista Chilena de Pediatría the year 1933].

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Updated: Jan 21, 2026

Rejection of Fluorescence Background in Resonance and Spontaneous Raman Microspectroscopy
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[Measles: Historical background and current situation].

Ricardo Fadic R1, Guillermo Repetto D2

  • 1Clínica Alemana, Facultad de Medicina, Universidad del Desarrollo, Chile.

Revista Chilena De Pediatria
|July 26, 2019
PubMed
Summary
This summary is machine-generated.

Measles remains a significant global health threat, particularly for children, due to low vaccination rates. Maintaining high vaccination coverage is crucial to control this re-emerging infectious disease.

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Area of Science:

  • Epidemiology
  • Public Health
  • Infectious Diseases

Background:

  • Measles significantly contributes to child morbidity and mortality globally.
  • Low vaccination coverage has led to measles becoming a global public health concern.
  • Despite an effective vaccine introduced in Chile in 1964, maintaining over 95% coverage is essential for control.

Purpose of the Study:

  • To review the historical context and current status of measles.
  • To highlight the epidemiological impact of measles on pediatric and adult populations.
  • To inform strategies for strengthening vaccination efforts, especially for travelers.

Main Methods:

  • Review of historical vaccination data in Chile.
  • Analysis of current global measles circulation patterns.
  • Examination of transmission dynamics, including imported cases and traveler transmission.

Main Results:

  • Chile's early mass vaccination campaign was a pioneering global success, drastically reducing measles rates.
  • Measles has re-emerged as a widespread issue, affecting over 160 countries.
  • Imported cases and infected travelers are primary drivers of current measles transmission.

Conclusions:

  • High vaccination coverage, exceeding 95%, is critical for measles control.
  • Strengthening vaccination strategies for susceptible populations, particularly travelers, is necessary.
  • Measles poses a significant, re-emerging epidemiological threat globally.