Related Experiment Video

Updated: Jan 21, 2026

Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens
06:02

Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens

Published on: January 31, 2016

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[Inflammatory myofibroblastic tumor: Variable presentation of the same pathology]

Jorge E Muñoz Moya1, María Olga Alfaro Aguirre1, Mauricio Leiva Silva1

  • 1Servicio de Cirugía infantil, Hospital Clínico San Borja Arriarán, Chile.

Revista Chilena De Pediatria
|July 26, 2019
PubMed
Abstract

Insights

Inflammatory myofibroblastic tumors are rare benign neoplasms with unpredictable behavior. Management of these tumors depends on location, ALK expression, and resectability.

Area of Science:

  • Pediatric Oncology
  • Surgical Pathology
  • Oncology

Background:

  • Inflammatory myofibroblastic tumor (IMT) is an infrequent benign neoplasm.
  • IMT exhibits unpredictable clinical behavior.
  • This study reviews three pediatric cases and relevant literature.

Observation:

  • Case 1: A 14-year-old male with jejunojejunal intussusception due to an intestinal IMT.
  • Case 2: A 12-year-old female with a retroperitoneal IMT involving multiple structures.
  • Case 3: An 11-year-old female with a bladder IMT.

Findings:

  • Histological analysis confirmed IMT in all three cases.
  • The cases highlight the diverse presentations of IMT in pediatric patients.
  • IMTs can occur in various locations, including the intestine, retroperitoneum, and bladder.

Implications:

  • Management strategies for IMT must be individualized.
  • Factors influencing treatment include tumor location, ALK expression, and resectability.
  • Further research is needed to understand and predict IMT behavior.

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