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Updated: Jan 21, 2026

Isolation of CD 90+ Fibroblast/Myofibroblasts from Human Frozen Gastrointestinal Specimens
Published on: January 31, 2016
[Inflammatory myofibroblastic tumor: Variable presentation of the same pathology].
Jorge E Muñoz Moya1, María Olga Alfaro Aguirre1, Mauricio Leiva Silva1
1Servicio de Cirugía infantil, Hospital Clínico San Borja Arriarán, Chile.
Inflammatory myofibroblastic tumors are rare benign neoplasms with unpredictable behavior. Management of these tumors depends on location, ALK expression, and resectability.
Area of Science:
- Pediatric Oncology
- Surgical Pathology
- Oncology
Background:
- Inflammatory myofibroblastic tumor (IMT) is an infrequent benign neoplasm.
- IMT exhibits unpredictable clinical behavior.
- This study reviews three pediatric cases and relevant literature.
Observation:
- Case 1: A 14-year-old male with jejunojejunal intussusception due to an intestinal IMT.
- Case 2: A 12-year-old female with a retroperitoneal IMT involving multiple structures.
- Case 3: An 11-year-old female with a bladder IMT.
Findings:
- Histological analysis confirmed IMT in all three cases.
- The cases highlight the diverse presentations of IMT in pediatric patients.
- IMTs can occur in various locations, including the intestine, retroperitoneum, and bladder.
Implications:
- Management strategies for IMT must be individualized.
- Factors influencing treatment include tumor location, ALK expression, and resectability.
- Further research is needed to understand and predict IMT behavior.
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