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High-throughput Screening for Protein-based Inheritance in S. cerevisiae
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Protein-based inheritance.

Johannes Manjrekar1, Hiral Shah1

  • 1Microbiology Department and Biotechnology Centre, The Maharaja Sayajirao University of Baroda, Vadodara, 390002, India.

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|July 26, 2019
PubMed
Summary
This summary is machine-generated.

Epigenetic inheritance, particularly via protein conformational changes like prions, offers a novel evolutionary mechanism. These protein-based epigenetic traits can be transmitted across generations, influencing cellular function, especially under stress.

Keywords:
AmyloidBet hedgingEpigenetic inheritanceEvolutionIntrinsically disordered proteinsPhase separationPrionsStress responses

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Epigenetic inheritance is crucial for understanding eukaryotes.
  • Transgenerational epigenetic inheritance is a significant area of research.
  • Protein conformational changes represent an under-discussed epigenetic mechanism.

Purpose of the Study:

  • To review epigenetic inheritance mediated by protein conformational changes.
  • To discuss the properties and implications of prions and prion-like proteins.
  • To explore the role of these proteins in cellular organization and stress responses.

Main Methods:

  • Review of existing literature on prions and prion-like proteins.
  • Analysis of protein conformational changes as an epigenetic mechanism.
  • Discussion of experimental evidence for transgenerational inheritance of protein structures.

Main Results:

  • Classical amyloid-forming prions and prion-like proteins propagate via structural templating.
  • Phenotypes associated with altered protein conformations are heritable.
  • Intrinsically disordered proteins with conformational plasticity play roles in cellular organization, particularly during stress.

Conclusions:

  • Protein conformational changes represent a significant, yet underappreciated, mode of epigenetic inheritance.
  • Prions and prion-like proteins have profound implications for evolution and cellular function.
  • Further research into these protein-based inheritance systems is warranted, especially concerning their role in stress adaptation.