Oxygen Therapy and Pulmonary Hypertension in Preterm Infants

The goal of oxygen therapy and oxygen saturation targeting in extremely preterm infants is to improve outcomes and balance the risks associated with both hypoxemia and hyperoxemia. Although the NeOProM trials addressed whether low or high oxygen saturation targets affect the most important outcomes of extreme prematurity including death and other co-morbidities, the trials did not evaluate infants for pulmonary hypertension. There is limited evidence for the optimal oxygen saturation targets in extremely preterm infants that can be used to prevent the development of pulmonary hypertension and manage pulmonary hypertension once developed.