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Updated: Jan 21, 2026
10:38
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
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The Changing Clinical Spectrum of Hypophysitis.
Sabrina Chiloiro1, Ettore Domenico Capoluongo2, Tommaso Tartaglione3
1Pituitary Unit, Department of Endocrinology, Fondazione A Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Trends in Endocrinology and Metabolism: TEM
|July 27, 2019
Summary
Hypophysitis, a rare disease, presents risks like hypoadrenalism and hypopituitarism. This review suggests a multidisciplinary approach for prompt diagnosis and safe treatment of hypophysitis.
Area of Science:
- Endocrinology
- Immunology
- Neurology
Background:
- Hypophysitis is a rare, life-threatening inflammatory condition affecting the pituitary gland.
- It carries risks of central hypoadrenalism, hypopituitarism, and neurological complications.
- Increased incidence is linked to the rise in immunotherapies.
Purpose of the Study:
- To review current data on primary and secondary hypophysitis.
- To propose a diagnostic and therapeutic protocol.
- To emphasize a multidisciplinary approach for improved patient management.
Main Methods:
- Comprehensive literature review of primary and secondary hypophysitis.
- Analysis of diagnostic criteria and treatment protocols.
- Synthesis of evidence to formulate a proposed management strategy.
Main Results:
- Current diagnostic criteria and treatment protocols for hypophysitis are heterogeneous, complicating patient management.
- A significant increase in hypophysitis cases is associated with recent advancements in immunotherapies.
- The review highlights the need for standardized approaches.
Conclusions:
- A multidisciplinary approach is crucial for the prompt diagnosis and safe treatment of hypophysitis.
- Standardized diagnostic and therapeutic protocols are needed to manage this complex condition effectively.
- Early and accurate management can mitigate severe complications associated with hypophysitis.
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