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Updated: Jan 21, 2026

A Simple Cell-based Immunofluorescence Assay to Detect Autoantibody Against the N-Methyl-D-Aspartate NMDA Receptor in Blood
Published on: January 9, 2018
Persistent extreme delta brush in anti-NMDA-receptor encephalitis: Does it portend a poor prognosis?
Muthukani Sankaranarayanan1, Shalin Shah1, Pravin Thomas1
1Department of Neurology, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Abstract:
We describe an adolescent girl with non-paraneoplastic anti-NMDA-receptor encephalitis (ANMDARE), who despite persistence of the extreme delta brush (EDB) pattern for nearly 2 years in her serial EEGs, she exhibited a speedy and sustained response to immunotherapy. To the best of our knowledge, our patient had the longest persistence of the EDB pattern on EEG reported to date. Our patient illustrates that, although presence of EDB supports the diagnosis of ANMDARE, its presence and persistence may not be a reliable predictor of response to immunotherapy and overall clinical prognosis.
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