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Updated: Jan 21, 2026

Fabricating Highly Open Porous Microspheres HOPMs via Microfluidic Technology
Published on: May 16, 2022
Comparative study of rheological properties and preclinical data of porous polycaprolactone microsphere dermal
Jin-Su Kim1, Chang-Hoon In1, Na-Jeong Park1
1Samyang Biopharmaceutical Corp. R&D Center, Seongnam, Korea.
Background:
In this study, a physical properties test and preclinical evaluation were performed on two polycaprolactone (PCL)-based dermal filler formulas.
Objective:
This study was performed to compare the rheological characteristics, preclinical efficacy, and safety of a new PCL filler, SF-01, with a licensed PCL filler.
Methods:
First, the viscoelasticity of the PCL filler was evaluated. Next, hairless mice were injected with fillers and evaluated for efficacy with a folliscope and PRIMOSLITE . Histological evaluation was conducted for 6 months to evaluate safety.
Results:
In this evaluation, SF-01 was superior to a licensed PCL filler in initial volume increase rate and in vivo durability, and the migration of the injected filler was not confirmed. The elasticity (G*, G') and viscosity (G'') are also expected to be lower than those of a licensed PCL filler, thereby resulting in less foreign body sensation in the living body.
Conclusion:
SF-01 (porous PCL microsphere-based dermal filler) has been confirmed to be superior in durability and shape retention compared to the licensed PCL filler (nonporous PCL microsphere-based dermal filler), and the in vivo safety is equivalent.
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